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Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of...

This volume deals with the various neurotransmitters (amino acids, biogenic amines, peptides) and their role in the control of behaviour and mood, both from the experimental and from the clinical and pharmacological point of view. The book provides a detailed discussion of how biological rhythms relate to changes in mood, and how the hypothalamus and pituitary hormones can be related to mood changes. Basic hints for diagnosis are also considered.