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In the present work, an attempt was made to formulate buccoadhesive gel for the treatment of oral submucousal fibrosis. The aim was to assess the influence of type and concentration of gelling agents: Carbopol 934p and sodium carboxy methyl cellulose on the quality attributes of buccoadhesive gel. All the proposed five buccoadhesive gel formulations were prepared. The prepared gels were evaluated and In-vitro release of metronidazole and lycopene at 240 min from buccoadhesive gel determined.The release of lycopene not satisfactory from optimized gel formulation, to increase the release of...