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Aurora kinases are the key regulators of cell cycle progression. Aurora-A and Aurora-B, expressed in somatic cells and are involved mainly in mitosis. Aurora-C is mainly expressed during gametomatogenesis and is involved in meiosis. Aurora-C is hardly detectable in normal somatic cells. The kinases are overexpressed in many cancer lines. Aurora-A possesses an oncogenic activity while Aurora-B does not. We investigated whether Aurora-C possesses such an oncogenic activity. We report that overexpression of Aurora-C induces abnormal centrosome amplification and multinucleation. The stable NIH3T3...