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This volume includes both asymptotic results on the inevitability of random knotting and linking, and Monte Carlo simulations of knot probability at small lengths. The statistical mechanics and topology of surfaces on the d-dimensional simple cubic lattice are investigated. The energy of knots is studied both analytically and numerically. Vassiliev invariants are investigated and used in random knot simulations. A mutation scheme which leaves the Jones polynomial unaltered is described. Applications include the investigation of RNA secondary structure using Vassiliev invariants, and the...