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ORIGINAL SIN opens with Kathryn Paige Harden taking LSD with her boyfriend in the West Texas desert, precipitating an experience in which he is unable to escape from the sense that he alone is responsible for an apocalyptic event, despite the fact that the event was impossible to avoid. Using this idea - of being born into sin, the eternal human paradox of free will versus destiny, sharpened to a razor edge by contemporary genetics - Harden explores some of the most important questions in philosophy: How are we to take responsibility for the individuals we become in light of what we know...