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This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide...

The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means...

In 1854, a group of engineers and railroad businessmen drew a straight line from Philadelphia to the New Jersey coast, built a railroad along the line, and created Atlantic City. From the 1850s to the 1950s, the city attracted the creme of American society and the working class alike and gave birth to the beauty pageant, rolling chair, boardwalk, saltwater taffy, jitney, and the successful Monopoly board game. But the onset of air travel in the 1950s and the aging grand hotels brought Atlantic City to its knees. The opening of Resorts International in 1978 and the prosperous gaming business...