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The emerging genomic, epigenomic, sensing and image technologies will produce a deluge of unprecedentedly massive and highly-dimensional genomic, epigenomic, physiological, image and clinical data. Goals of this book are to develop unified frameworks, basic knowledge and efficient computational tools for analyzing growing large, complex and diverse genomic, epigenomic, physiological and image data. The book is designed to introduce the currently developed statistical methods and software for big genomic and epigenomic data analysis with real-world examples and case studies.