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A variety of imidazole, and fused imidazole derivatives have been reviewed. Continuous efforts on combination of lead optimization and molecular modeling studies in synthesis and the structure activity relationship studies and biological activities of novel modi ed imidazole, and fused imidazole derivatives, allowed to identi cation of novel imidazole derivatives as potent anti TB, antimicrobial and antidepressant agents."

A variety of five membered N-heterocyclic derivatives have been reviewed. Based on brief review, the compounds have been subjected for assessment of their pharmacological activities, and it's believed that these compounds found to be the most active for their further studies. The objective of this review is to systematically evaluate the pharmacological properties of various substituted five membered N-heterocyclic compounds and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies.