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First published in 1986, this unique reference to clinical experimentation remains just as relevant today. Focusing on the principles of design and analysis of studies on human subjects, this book utilizes and integrates both modern and classical designs. Coverage is limited to experimental comparisons of treatments, or in other words, clinical studies in which treatments are assigned to subjects at random.

This book is to be recommended as a standard shelf reference. and as a 'must' to be read by all who wish to better use and understand data involving dichotomous or dichotomizable measurements. American Journal of Psychiatry In the two decades since the second edition of Statistical Methods for Rates and Proportions was published, evolving technologies and new methodologies have significantly changed the way today's statistics are viewed and handled. The explosive development of personal computing and statistical software has facilitated the sophisticated analysis of data, putting capabilities...