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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and...

Hardbound. In the foreseeable future the alliance will become an increasingly important feature of the airline industry around the world. Despite its growing importance to airline management, aviation policy makers, and research literature, there has not been much rigorous analysis of airline alliances in economics or management literature. It is clear that the authors of this book are among the first researchers to do serious analytical studies and quantitative analysis on airline alliances. Given the growing importance of alliances, there is a clear need for a book that gives a...