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In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on...

Authoritative and easy to use, this reference is of great value to the molecular biologist or computational biologist who wants to understand the principles of these analyses or plan future experiments using microarrays to characterize the physical genome.

This book chronicles the political-military development of the Korean Peninsula since 1945, with particular attention to North Korea‘s pursuit of nuclear technology and nuclear weapons, and how it has shaped Northeast Asian security and non-proliferation policy and influenced the strategic choices of the United States and all regional powers. I focus on North Korea‘s leaders, institutions, political history, and the system‘s longer-term prospects. How has an isolated, highly idiosyncratic, small state repeatedly stymied or circumvented the policy preferences of much more powerful...

Best known for his epic Lord of the Rings trilogy and The Hobbit, J.R.R. Tolkien was born in British-occupied South Africa. His early life was full of action and adventure. Tolkien spent his childhood roaming the British countryside with his family and could read and write by age four. He was naturally gifted with languages and used this skill as a signals officer in World War I as well as in his fantasy writing. By creating alternate universes and inventing languages in his work he demonstrated that imaginary realms were not just for children. Fondly remembered as the "Father...