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The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to...

Emerging Infections is a reprint of the inaugural volume of the thematic serial, Biomedical Research Reports Series that provides annual updates on hot topics of interest to a broad spectrum of the biomedical research community. This volume provides state-of-the-art reviews of the most important "new" and reemerging bacterial, viral, and parasitic infections, their life cycles, host defense evasion strategies, and clinical features. Emerging Infections includes in-depth coverage of the history of infectious disease outbreaks, population and evolutionary biology of human...

Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications.

In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and "omic" platforms, this edition...