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This book constitutes the refereed joint proceedings of the 1stInternational Workshop on Ethical & Philosophical Issues in Medical Imaging (EPIMI 2022); the 12thInternational Workshop on Multimodal Learning and Fusion Across Scales for Clinical Decision Support (ML-CDS 2022) and the 2ndInternational Workshop on Topological Data Analysis for Biomedical Imaging (TDA4BiomedicalImaging 2022), held in conjunction with the 25th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2022, in Singapore, in September 2022.EPIMI includes five short papers about various...