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The test drug, CA (Triterpenoid glycoside) at 30 mg /kg oral dose was found to be the most significant antidepressant activity in comparison to imipramine 100mg/kg p.o. and fluoxetine 100mg/kg p.o. In the forced swim and tail suspension test the test drug, CA (Triterpenoid glycoside) showed a dose dependent activity on immobility. The test drug, CA (Triterpenoid glycoside) has significant increase in locomotor activity; therefore, the test drug is devoid of sedative effect. The mechanism of action of the test drug was different from imipramine, so, the test drug is not a reuptake inhibitor of...

Intellectual Property means those creations of the legal mind in relation to which the state confers upon individuals a statutory monopoly for a prescribed term to prevent their unauthorised exploitation and Patent is nothing but the Intellectual property. A patent is an exclusive right awarded to an inventor of a product or process, which prevents others from making, selling, distributing, importing or using the invention, without licence or authorization, for a fixed period of time. A patent claim relating to a pharmaceutical product may relate to an active ingredient as such independently...

Conventional oral dosage forms provide a specific drug concentration in the systemic circulation without offering any control over the rate of drug delivery. Controlled-release drug delivery systems (CRDDS) provide drug release at a predetermined, predictable, and controlled rate. It was attempt to develop a gastro retentive drug delivery system of anti hypertensive drug using different polymers like that HPMCK4M, Xanthangum, PolyoxWSR303as matrixing agent, swelling agent, respectivel. A simplex lattice design was applied to combined effect of three formulation variables (ie, amount of...

The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.)...