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The discrete gradient method is proposed as a novel numerical tool to perform solid mechanics analysis directly on point-cloud models without converting the models into a finite element mesh. This method does not introduce continuous approximation of the primary unknown field variables; instead, it computes the gradients of the field variables at a node using discrete differentials involving a set of neighboring nodes. Therefore, the formulation renders a completely discrete computation that can conduct mechanical analysis on point-cloud representations of patient- specific organs without...

This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the “post-structural biology” era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition...