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Mixed-effects models have found broad applications in various fields. As a result, the interest in learning and using these models is rapidly growing.

In a way, the world is made up of approximations, and surely there is no exception in the world of statistics. In fact, approximations, especially large sample approximations, are very important parts of both theoretical and - plied statistics.TheGaussiandistribution, alsoknownasthe normaldistri- tion, is merelyonesuchexample, dueto thewell-knowncentrallimittheorem. Large-sample techniques provide solutions to many practical problems; they simplify our solutions to di?cult, sometimes intractable problems; they j- tify our solutions; and they guide us to directions of improvements. On the...

Large sample techniques are fundamental to all fields of statistics. Mixed effects models, including linear mixed models, generalized linear mixed models, non-linear mixed effects models, and non-parametric mixed effects models are complex models, yet, these models are extensively used in practice. This monograph provides a comprehensive account of asymptotic analysis of mixed effects models.

The monograph is suitable for researchers and graduate students who wish to learn about asymptotic tools and research problems in mixed effects models. It may also be used as a reference book...

Over the past decade there has been an explosion of developments in mixed e?ects models and their applications. This book concentrates on two major classes of mixed e?ects models, linear mixed models and generalized linear mixed models, with the intention of o?ering an up-to-date account of theory and methods in the analysis of these models as well as their applications in various ?elds. The ?rst two chapters are devoted to linear mixed models. We classify l- ear mixed models as Gaussian (linear) mixed models and non-Gaussian linear mixed models. There have been extensive studies in...

Plant Centromere Biology is dedicated to plant centromere research. Chapters cover the structure of centromeres from several plant species including Arabidopsis thaliana, rice, maize, wheat and beet, while other sections cover several unique characteristics associated with plant centromeres, including classical and modern neocentromeres, centromere drive and centromere misdivision. Additional chapters are dedicated to epigenetic modification and evolution of plant centromeres, and development and application of plant artificial chromosomes.

Written by an international group...