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The emergence of the niche field of osteoimmunology represents a conceptual rethinking of multiple phenomena, relating biological events in bone and the immune system. The rationale for studying "Osteoimmunology" is to understand how bone influences immune and hematopoietic cells as well as how hematopoietic and immune cells influence bone. This interdisciplinary field of study, which emerged almost a decade ago, integrates the disciplines of immunology and bone biology and has served as a useful framework for improving our understanding of pathogenesis of Periodontal Disease.