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Cell migration is accomplished by chemoattractant receptors signaling the spatially-restricted activation of rho gtpases. specifically, chemoattractant receptors signal via gai and downstream guanine nucleotide exchange factors (gefs), p-rex and pixa, to activate rac and cdc42 at the leading edge and ultimately leads to cellular protrusion. In contrast, chemoattractant receptor signaling by ga12/13 activate rhoa at the trailing edge and promote cytoskeletal contraction. however, the gef(s) that activate rhoa downstream of chemoattractant receptor and ga12/13 have not been identified. here...

With the rapid growth of global industrialization, there has been substantial consumption of fossil fuels such as coal, petroleum, and natural gas along with growing carbon dioxide emissions. Unprecedented environmental and ecological crisis clouded the world. Fortunately, the Climate Conference in Copenhagen signaled hope amid the sluggish global economic recovery. Countries worldwide have been braced for developing their scientific and industrial strategies in the era of post financial crisis with a green and low-carbon philosophy. In 2008, the UN unveiled a plan for green politics and...

The "International Workshop on Satellite Altimetry for Geodesy, Geophysics and Oceanography: Summer Lecture Series and Scientific Applications" was held in Wuhan, China from September 8 to 13, 2002 (http: //space. cv. nctu. edu. tw/altimetryworkshop/altimetry. htm). This is a joint workshop ofInternational Association ofGeodesy (lAG) Special Study Group (SSG) 3. 186 (chaired by C. Hwang ofNational Chiao Tung University) and lAG Section II (President: C. K. Shum of the Ohio State University), and was hosted by Wuhan University with J. C. Li as the chair ofthe local organizing committee. The...