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This monograph introduces the excellent application of olefin metathesis approah for total synthesis biologically potent 10-membered lactone derived natural products, such as (+)-Mueggelone (a novel inhibitor of fish development), Herbarumin-I (Which interacts with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase and should have physiological effects of agrochemical and medicinal interest), and Stagonolides (which were shown to be a nonhost-speci c but selective phytotoxin. Leaves of C. arvense were most sensitive and leaves of...

This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. (-)-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterases, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique...