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This study aimed to investigate the protective effect of an antioxidant vitamin C against sodium arsenite-induced male reproductive toxicity as arsenic affects reproductive system by producing ROS. The treatment of mature guinea pigs with sodium arsenite (5mg/kg body weight/day) for period of 28 days reduced DSP, testosterone concentration and body, testis, epididymes and liver weight along with marked accumulation of arsenic in blood, liver, testis, epididymes and vas deferens. Sodium arsenite reduced seminiferous tubule diameter, epithelial height, tunica albuginea thickness, nuclear...