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As the twenty-first century unfolds, medicine is facing several significant challenges that threaten to cripple its advancement and practice. One of the responses to these challenges is the emergence of systems medicine, and one of the more pertinent challenges is identifying and clarifying systems medicine’s conceptual and theoretical foundations. This book represents a sustained effort to examine this challenge and to map the terrain by which to engage it and to pursue possible solutions. This conceptual and theoretical challenge in particular needs to be addressed to ensure the future...