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This book provides a comprehensive overview of the hypoxic tumor microenvironment and its impact on various aspects of cancer biology, including DNA damage response, genome instability, tumor immunity, non-coding RNA regulation, metabolic regulation of CAR-T cell function, and angiogenesis. It explores the regulation and therapeutic potential of hypoxia-inducible factors, as well as strategies to improve cancer immunotherapy by targeting the hypoxic tumor microenvironment. This book is a valuable resource for students, researchers, and Medical science professionals interested in...

This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune...