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In this book, emphasis is placed on the scientific background leading to the discovery of valproate, and its clinical development into one of the most widely used antiepileptic drugs, a milestone in drug therapy. It reviews the state of the drug, and looks at hypotheses on its mechanisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, and its various clinical uses.

Haemodynamics and Immune Defence: Discoveries in Pharmacology, Second Edition, Volume Three presents selected articles from the historic Discoveries in Pharmacology series that are enhanced with commentary from contemporary scholars who discuss the reception and importance of each chapter along with an updated bibliography on the subject and contributions from those involved in Nobel Prize winning discoveries and pioneering advancements in Pharmacology. This volume brings forth discussions on key discoveries in hemodynamics and immune defense, including chapters on penicillin by Dr. Selwyn...