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Introduction This study was designed as a clinical trial to evaluate and compare the regenerative potential of Platelet rich Fibrin, Platelet rich Plasma and Blood Clot in immature necrotic permanent teeth with or without associated apical periodontitis. Methods Access preparation was done under rubber dam isolation. Copious irrigation was done with 2.5% NaOCl and triple antibiotic paste was placed as an intracanal medicament. After 4 weeks, the cases were divided into four groups. The study design had 3 test arms (Blood clot, PRP and PRF) and 1 control arm (Apexification). Results ...