Metallo-Drugs: Development and Action of Anticancer Agents

ISBN-13: 9783110469844 / Angielski / Twarda / 2018 / 588 str.

Imogen Riddell;Stephen J. Lippard;Victor Brabec

Opis

The Sigels' Series Metal Ions in Life Sciences Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. It is an old experience that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, materials sciences, molecular and structural biology, biophysics, enzymology, environmental chemistry, physiology, toxicology, pharmacy, medicine, and others. Indeed, already for years this ..".series is (praised as) a timely resource" D. Wilcox, J. Am. Chem. Soc. (2009)] ..".a compilation of an incredible amount of research" K. Duncan, Angew. Chem. Int. Ed. (2009)] ..".a must for ... bioinorganic research labs" P. Sadler, Chemistry World (2009)] ..".(a) stimulate (for) the combined action of chemists, biologists, medical doctors, and physicists to contribute to new developments in the field" G. L. Squadrito, J. Am. Chem. Soc. (2007)] ..."The editors have without question been at the forefront of promoting Biological Inorganic Chemistry over many years and this latest volume is no exception" C. J. Marmion, Trans. Met. Chem. (2014)] ..".it is a must to have" L. Quintanar, J. Inorg. Biochem. (2016)] ..."I strongly suggest that (the volumes) should reside on the bookshelves of bioinorganic chemists, ... biochemists, biophysicists (and others) interested in the diverse ... functionscarried out by metal ions in biology" K. D. Karlin, Inorg. Chim. Acta (2016)] ..."The articles (in the series) will greatly help to overcome (the) language barrier(s) between the historically separate disciplines of chemistry, biology, medicine, and physics that hinders progress" P. J. Sadler, Coord. Chem. Rev. (2014)] ..."(Furthermore)...Experts will find countless pieces of information that they might not have been aware of and students ... will appreciate ... (appealing) introduction(s) to an interdisciplinary field that continues to grow (rapidly) and provides future challenges for basic research and the applied sciences" M. Egli, Trans. Met. Chem. (2016)] Clearly, the MILS series is an essential source for researchers as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. Individual chapters can be downloaded.

Recenzje

"The editors are to be congratulated for not only keeping the scientific community abreast of latest developments in this vibrant field of research but for providing an invaluable resource which will no doubt stimulate further cutting edge research in this domain. This volume will also act as an invaluable and indispensable reference source for postgraduate as well as undergraduate teaching. I cannot recommend it highly enough."
Celine J. Marmion in: Coordination Chemistry Reviews 371 (2018) 96-98

"(...) Metallo-Drugs: Development and Action of Anticancer Agents is a nice collection of articles that serves a suitable introduction to either the novice or experienced researcher in the field."
Seth M. Cohen in: Journal of Inorganic Biochemistry 186 (2018) 103

"Volume 18 of MILS is an excellent update on a vibrant field within Bioinorganic Chemistry, the role of metal species in the treatment of cancer. It reflects both the successes of metallo-drugs in the clinic, their failures and shortcomings, and at the same time also promises and hopes for improved drugs in the future. The book is, as stated by the editors, indeed an "essential resource for scientists in this field" and a valuable source for teachers of relevant Bioinorganic Chemistry courses."
Bernhard Lippert in: Inorganica Chimica Acta 479 (2018) 247-248

"(...) This volume currently represents the most up-to-date review within the field of metal-based anticancer agents. (...) A particular strength is the focus on the mechanistic studies and the biological targets, an important feature that makes it different from other reviews recently published. (...) The volume Metallo-Drugs: Development and Action of Anticancer Agents is strongly recommended not only to experienced scientists (either chemists, biologists, biochemists or pharmacologists), but also to researchers in the early stage of their career willing to gain preliminary knowledge on metallodrugs and their biological activity, so as acquire the theoretical background necessary to carry our successful research in the field."
Luca Ronconi in: Transition Metal Chemistry 43 (2018) 377-379

"This latest volume of the series on Metal Ions in Life Sciences will be a valuable addition to libraries of researchers and institutions active in cancer research, but also a helpful source for advanced teaching of the subject."
Hubert Schmidbaur in: Zeitschrift für Naturforschung B 73 (2018) 355-357

Spis treści

From the Content:

1. Introduction to the Wider Field of Metallo-Drugs
2. Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions
3. Polynuclear Platinum Drugs: Covalent and Non-covalent DNA-Binding Agents
4. Different Drugs, Different Actions: The Actions and Consequences of Trans and Cationic Platinum Drugs
5. Platinum(IV) Drugs
6. The Ruthenium Drugs KP1019 and NAMI-A: Our Current Understanding of Their Actions
7. Ruthenium Piano-Stool Organometallic Drugs
8. The Gold Drugs
9. Titanium Drugs
10. Vanadium Drugs
11. Non-covalent Metallo-Drugs: Targeting Junction Structures
12. Metallo-Drugs that Target Proteins
13. Non-canonical Nucleic Acid Targets: Metallo-Drugs that Act on Quadruplexes
14. Targeting, Delivery and Nanoscience of Metallo-Drugs
15. Metallo-Intercalators

O autorze

Helmut and Astrid Sigel, University of Basel, Switzerland; Roland K. O. Sigel and Eva Freisinger, University of Zürich, Switzerland.