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"She remembered learning from the bear man shortly after the incident that two German soldiers were killed by a third. Perhaps he was the one who took their lives. She believed that if she were ever to find out the answers, now was not the time to deluge him with her emotions and questions.

Her persistent gaze released a rush of memories flooding Selig's mind. In the secret space of his consciousness he saw a young,...

"She remembered learning from the bear man shortly after the incident that two German soldiers were killed by a third. Perhaps he was the one who took their lives. She believed that if she were ever to find out the answers, now was not the time to deluge him with her emotions and questions.

Her persistent gaze released a rush of memories flooding Selig's mind. In the secret space of his consciousness he saw a young,...

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration...