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Aging can be viewed partly as a degenerative process dictated by free radical reactions. Human diploid fibroblasts (HDFs) lose the capacity to proliferate and enter a state termed replicative senescence after a finite number of population doublings in vitro. Presenescent human fibroblasts, when treated with a sub-lethal dose of H2O2, enter long term growth arrest resembling replicative senescence. H2O2 induced growth arrest; p53 protein expression and the effect of vitamin C as an antioxidant were determined in this study.

Breast cancer is a global public health burden. The stage at diagnosis is an important predictor of patient outcome. Thus there is an urgent need for developing more robust biomarkers. The discovery of circulating microRNAs along with their important role in cancer initiation and progression highlights their potential use as a non-invasive biomarker for cancer detection, evaluation, and follow-up. MicroRNA-21, in particular, has attracted a great deal of attention, since it is one of the most highly up-regulated microRNAs in many cancers. Herein, serum microRNA-21 levels were assessed in...