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Grp170 is a major molecular chaperone/stress protein resident in the ER. It is distantly related in sequence to both hsp110 and hsp70 families. Although most chaperones are intracellular proteins they can be modified into secretory proteins. Chaperones secreted into the tumor microenvironment can recruit professional APCs and promote antigen presentation and priming of T-lymphocytes. This book describes an approach to target grp170 to the tumor microenvironment, which results in tumor rejection mediated by an adaptive immune response that is CD8+ dependent and accompanied by an enhanced...