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The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900's. Three enzymes, cystathionine -synthase (CBS), cystathionine -lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H₂S in vitro. However, H₂S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980's relatively high concentrations of sulfide were measured in the brain that led to the successive...

This book covers H2S, which is produced in almost every organ, and its role in neuromodulation, vasodilation, insulin release, inflammation, angiogenesis, cytoprotection and in disease pathogenesis. Includes biological research and therapeutic development.