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The book lays out the evolutionary, historical and scientific evidence that a psychological immune system exists and details how this system functions and the impact it has had on our personal, social and national life. It shows ways that it can be helpful in our attempt to identify and handle the threats and dangers that face us just as our biological immune system does. And, like our biological immune system, it has the potential to be both beneficial and lethal.

We have been endowed with a symbolic brain that helps us adapt to and survive in our natural and man-made worlds. However it is open to both true and false beliefs both of which have impacts on our well-being. Supernatural beliefs may lead to disastrous consequences but continue to exist because they actually serve human survival through their reliance on faith and reduction of stress. So our symbolic brain's readiness for supernatural beliefs is a mixed blessing-but a blessing nevertheless.