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Considering stress, this text covers the discovery of stress; the dissection of stress; the disease of adaptation; and implications and applications. Annotated references are also included.

7 If so, the individual members of each class thus identified could then be subjected to a more profound pharmacokinetic analysis. In other words, we had to determine first which hormone protects against which drug, before we could explore how it did this. We had to know first that a hormone has adaptive value before we could ask whether this is due to a syntoxic or a catatoxic mechanism. Such observations, as the fact that an indomethacin-induced intestinal ulcer can be prevented by ethylestrenol, orthat cortisol aggravates certain infections, reveal nothing about how these hormones work;...

Dr. Selye speaks many languages but the most important one he knows is the language of life, and it is in this language that he teaches us the pleasure and excitement of being out in the unknown with no footprints to guide us. Albert Szent-Gyorgyi, M.D., Ph.D., from the Foreword"