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In the late 1940s investigators observed that mice given supralethai doses of total body irradiation were protected by infusion of viable spleen or marrow cells following irradiation, and that this was accomplished by hemopoietic reconsti tution with donor cells as proven using genetic markers. If a similar approach could be applied to humans, it should be possible to treat leukemia patients with any dose of chemoradiotherapy as far as nonmarrow toxicity permitted, and then rescue them by marrow transplantation. Early clinical attempts were gen erally unsuccessful, mostly due to a lack of...

In 1988 we presented our Guide to Bone Marrow Transplan tation. The reception has been enthusiastic and we have re ceived a flood of critical comments, suggestions and requests to provide an update in due time. Although several books on marrow transplantation have recently been published, their scope and goal have generally been different. Hence, we have decided to prepare a second edition of the Guide. Our aim was to maintain a short, concise text which never theless would incorporate changes that have occurred over the past four or five years. We have streamlined the description of...

This third edition continues the idea of the previous version to provide an overview of blood and marrow transplantations. It discusses indication and transplanation and pre-transplant considerations, then transplant procedures with all acute and delayed procedure. An outlook on developments and their future prospects is included, and problems and pre- and post-transplant complications are discussed. The text seeks to help practising haematologists, oncologists and other physicians, as well as physicians in training and students, to develop an idea as to when blood and marrow transplantation...

This 2007 volume presents the lectures from the sixteenth Winter School of the Instituto de Astrofisica de Canarias, which was dedicated to extrasolar planets. Research into extrasolar planets is one of the most exciting fields of astrophysics, and the past decade has seen a research leap from speculations on the existence of planets orbiting other stars to the discovery of around 200 planets to date. The book covers a wide range of issues, from the state-of-the-art observational techniques used to detect extrasolar planets, to the characterizations of these planets, and the techniques used...