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It is now widely accepted that glutamate is the major excitatory neurotrans mitter in the mammalian central nervous system. The main criteria for accept ing a molecule as a chemical transmitter appear to be fulfilled at several synapses: Glutamate mimics the action of the natural transmitter in the post synaptic neuron (CURTIS et al. 1959), glutamate is present in presynaptic ele ments (OTTERSEN and STORM-MATHISEN 1984), and glutamate is released from central neurons in an activity-dependent manner (BRADFORD 1970). The postsynaptic receptors that mediate the effects of glutamate are markedly...