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Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and...