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This text covers three centuries from the invasion of Egypt by Alexander the Great to the death of Cleopatra VII (320-30 BC). From their base in Egypt, the Ptolemies created the most powerful empire in the eastern Mediterranean, extending from the Great Syrte in Libya to Palestine, Syria, Cyprus and Asia Minor. From 200 BC the Ptolemies gradually lost their wider empire as a result of conflict within the growing power of Rome.