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An International IMPAC Dublin Literary Award Nominee

A Toronto Globe and Mail Best Book of the Year

Conspiracies, plots, and paranoia are sweeping through London in the last days of the eighteenth century, and James Tilly Matthews has been caught under false pretenses and locked up in the city's vast, crumbling asylum. As his wife, Margaret, tries desperately to free him, political forces conspire to keep him locked up. Margaret's chief adversary is John Haslam, the asylum's chief apothecary, a man torn between his conscience and the lure of scientific...