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This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view.  The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural...

Since its foundation in 1766, Addenbrooke's Hospital has strongly influenced both the development of medical practice and the social history of Cambridge. As one of Britain's first Voluntary Hospitals serving the needs of the sick, and as a center of medical teaching, Addenbrooke's has always been a focal point in the community as well as a prestigious institute in the wider medical sphere. This authoritative and absorbing account of the Hospital traces in detail its history and development, from its benefaction in 1719 by John Addenbrooke, through its early years of expansion, reforms, and...