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The activation of the endothelium with various stimuli such as thrombin leads to cell shape change, migration, and proliferation that involve dynamic changes of the actin cytoskeleton. The Rho family GTPases activate Rho-kinase and PAK, which stimulate LIM-kinases. LIM-kinases regulate the actin cytoskeleton through phosphorylation of cofilin. Only very few studies reported about other functions of LIM-kinases, such as its possible role in cell cycle regulation. The function of the LIM-kinases is unknown in endothelial cells. In this study, we answered the following questions: 1. Which...