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P-glycoprotein (P-gp) known as multi drug resistance (MDR) protein was discovered by Juliano and Ling in 1976 and belong to the adenosine triphosphate (ATP)-binding cassette sub-family B member 1 (ABCB1). Active pharmaceutical ingredients, natural constituents, and pharmaceutically inert excipients have been widely studied as P-gp inhibitors. Three excipients ghee, badam oil and fenugreek oil were selected as excipients as there are enriched with p-gp substrates. Molecular docking studies were conducted to identify the binding energy involved in between p-gp and the components of selected...