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It is now almost a decade since the identification of the Huntington's Disease gene and its mutation. Major advances in our understanding of the disorder have been made during this time. Since publication of the first two editions, much more extensive evidence exists on how the HD mutation actually causes brain pathology. Experimental tools are now available to take this research further towards new therapeutic approaches.
Due to these major changes, this well-established book has been radically updated. An international group of leaders in their particular fields cover the major recent...

This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002.

Completely updated and expanded, chapters in this volume are organized in five sections:

- Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages

- The genetics of...