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Most of the developments in perioperative medicine the 20th century were focused on the establishment of standard monitors, biomarkers, and outcomes measures for the cardiovascular and respiratory systems, with marked improvements in perioperative safety. The fields of anesthesiology and perioperative medicine have now shifted to the consideration of the nervous system. Complications such as delirium, cognitive decline, anesthetic neurotoxicity, stroke and other devastating nervous system events are only now developing significant scientific and clinical attention. Yet, there has been no...

Hypnosis, amnesia, and immobility are three major therapeutic endpoints of general anesthesia. In one to two cases out of a thousand, hypnosis and amnesia are not achieved often leaving a patient immobile but capable of experiencing and remembering intraoperative events. Awareness during general anesthesia is one of the most dreaded complications of surgery and is feared by patients and clinicians alike. Despite many advances in the field, there are also a number of unresolved questions that persist. Some of the difficulties in the detection and prevention of awareness during anesthesia...

Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and...