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Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of...

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of...

Earthquake Protection of Building Equipment and Systems presents a framework for applying the latest earthquake engineering research to the nonstructural elements of individual building projects, concentrating on mechanical and electrical systems. The seismic performance of these systems and their components is critical in order to minimize damage and life-threatening risks associated with seismic events while also protecting capital investment. And just as the seismic engineering of structures is shifting from prescriptive-based standards to performance-based approaches, the same...

Accused of terrible war crimes that he can't remember committing, the Eleventh Doctor goes on the run with his companion Alice Obiefune, along with a mysterious amnesiac who calls herself The Squire As they dig deep into the history of the Time War in hope of clearing the Doctor's name, the bounty hunter called The Then and The Now, a hideous perversion of spacetime, tracks them at every turn

The all-new comics adventures of the Eleventh Doctor, as played by Matt Smith, have become a...