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SLE is similar to liquid-liquid extraction (LLE), but it's done using a cartridge or 96 well plate. It does not form emulsions like LLE, and removes phospholipids, salts and proteins. Most samples that can be cleaned up using LLE can be processed using SLE. An aqueous sample is loaded onto a cartridge packed with the SLE extraction media. The ISOLUTE SLE+ is a refined, porous, highly purified diatomaceous earth. The sample is absorbed onto the solid and dispersed as small droplets. Next, a water immiscible solvent is added. Compounds partition into the organic phase just like LLE, except...