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Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by a progressive memory decline, impairments in language and visual spatial skills, impairments in behavior, resulting in a loss of independence, reduction of quality of life, and ultimately death. In the present study, we have described a facile synthesis of novel promising anti-Alzheimer's disease steroidal curcumin derivatives and investigated the importance of incorporating heterocylic moiety to the curcumin nucleus to form new effective hybrid molecules All the tested compounds have been...

Inflammatory diseases are widely prevalent throughout the world. The identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. Developing new therapeutic agents that can overcome gastrointestinal injury and at the same time could lead to an enhanced anti-inflammatory effect becomes an urgent need for inflammation patients. This book provides new insights for developing new modified steroids with structures justifying non-ulcerogenic, anti-inflammatory and anti-nociceptive activities. The steroid...