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A simple, rapid and sensitive extractive Spectrophotometric method was developed for drug determination in pure and pharmaceutical preparations via ion pair formation with some dyestuff reagents namely bromothymol blue (BTB), bromophenol blue (BPB) and eriochrome blue black R (EBBR), Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations.

Part I: The utility of some -acceptors as TCNQ, DCQ, DDB and -acceptor as I2 for spectrophotometric estimation of etamsylate and tranexamic acid drugs. Part II: It deals with the spectrophotometric determination of etamsylate drug via oxidation-reduction reaction using iodic acid. Part III: It deals with the spectrophotometric determination of tranexamic acid drug via Schiff base formation using salicylaldahyde. Thus the proposed methods can be used for routine analysis of the suggested drugs in pharmaceutical preparations."