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The pyrazole nucleus has many biological activities, including several pharmaceuticals currently on the market. Thiazoles are additionally significant class of heterocyclic compounds, found in numerous powerful biologically active drugs such as Ritonavir (antiretroviral drug), Sulfathiazol (antimicrobial drug), Tiazofurin (antineoplastic drug), and Abafungin (antifungal drug). Thiazole derivatives are also known to possess several anticancer activities. Moreover, thiazolyl-pyrazole compounds were identified as as potential anticancer agents. The EGFR PTKs have been identified as interesting...

Multicomponent reactions has picked up surprising consideration in the field of organic synthesis and chemical biology due to the various preferences such as plausibility of a few bonds arrangement in one-step prepare in addition to significant benefits like reducing waste production, the superior atom economy, quick, efficient, and time-saving way without the separation of any intermediates, decrease of work ups, and easy straightforward experimental techniques that resulted in the green transformations. Pyridopyrimidines exhibit important biological and medicinal relevance such as...