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This open access book considers the role of uncertainty in the design and development of large-scale engineering systems. The focus of the book is the safe behaviour of nuclear power plants in both routine operations and in incident situations. The book introduces various types of uncertainty and addresses the extent to which uncertainties may be reduced. The role of multiple dimensions of uncertainty is discussed, as is the importance of modern computational techniques in handling large data sets. Modern IT also provides engineers with new tools, such as digital twins with the potential...