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America is a nation where a strong entrepreneurial culture establishes favorable conditions for subsequent entrepreneurship activity. I develop and test a model that comprises the determinants and consequences of new venture creation in American counties. The empirical results using a sample of 2,300 counties support direct and mediation effects between determinants of new venture creation and economic development and growth. This study contributes to knowledge by empirically testing an existing framework of entrepreneurship as well as assessing how new venture creation improves the economic...