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The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired haemorrhagic and thrombotic disorders. Its role in the monitoring of traditional anticoagulant therapy, as well as therapy using new anticoagulants, presents new challenges to the laboratory. This new edition addresses these important issues, as well as international guidelines for testing, the development of international standard materials, management of haemostasis testing from the laboratory to the point-of-care, and molecular genetic testing.