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Protein Arrays: Methods and Protocols is an introduction to protein array technology and its application to the multiplexed detection of proteins. Although protein array technology has some roots in gene array technology, it can only be described as a distant relative. Unlike DNA, with its established rules of base pairing, and therefore predictable biochemical behavior, proteins are rich with diversity. Proteins can be large or small, compact or extended, basic or acidic, hydrophobic or hydrophilic, and so on. Just as importantly, their behavior is determined by the environment in which they...

This volume introduces protein array technology and its application to the multiplexed detection of proteins. It opens with novel methods to construct protein arrays using biotin, chemical reagents and chromatographic substrates. Other chapters cover more specific applications such as identifying proteins that bind to certain protein domains, analyzing protein kinase activity, assessing protein families and probing serum for diagnostic information, making this an invaluable source for protein biochemists, and pharmaceutical scientists.